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1.

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.

Koikawa, Kazuhiro; Kibe, Shin; Suizu, Futoshi; Sekino, Nobufumi; Kim, Nami; Manz, Theresa D; Pinch, Benika J; Akshinthala, Dipikaa; Verma, Ana; Gaglia, Giorgio; Nezu, Yutaka; Ke, Shizhong; Qiu, Chenxi; Ohuchida, Kenoki; Oda, Yoshinao; Lee, Tae Ho; Wegiel, Babara; Clohessy, John G; London, Nir; Santagata, Sandro; Wulf, Gerburg M; Hidalgo, Manuel; Muthuswamy, Senthil K; Nakamura, Masafumi; Gray, Nathanael S; Zhou, Xiao Zhen; Lu, Kun Ping.

Cell; 184(18): 4753-4771.e27, 2021 09 02.

Artículo en Inglés | MEDLINE | ID: mdl-34388391

2.

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

Bester, Assaf C; Lee, Jonathan D; Chavez, Alejandro; Lee, Yu-Ru; Nachmani, Daphna; Vora, Suhani; Victor, Joshua; Sauvageau, Martin; Monteleone, Emanuele; Rinn, John L; Provero, Paolo; Church, George M; Clohessy, John G; Pandolfi, Pier Paolo.

Cell; 173(3): 649-664.e20, 2018 04 19.

Artículo en Inglés | MEDLINE | ID: mdl-29677511

3.

PI3K drives the de novo synthesis of coenzyme A from vitamin B5.

Dibble, Christian C; Barritt, Samuel A; Perry, Grace E; Lien, Evan C; Geck, Renee C; DuBois-Coyne, Sarah E; Bartee, David; Zengeya, Thomas T; Cohen, Emily B; Yuan, Min; Hopkins, Benjamin D; Meier, Jordan L; Clohessy, John G; Asara, John M; Cantley, Lewis C; Toker, Alex.

Nature; 608(7921): 192-198, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35896750

4.

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia.

Lee, Jonathan D; Paulo, Joao A; Posey, Ryan R; Mugoni, Vera; Kong, Nikki R; Cheloni, Giulia; Lee, Yu-Ru; Slack, Frank J; Tenen, Daniel G; Clohessy, John G; Gygi, Steven P; Pandolfi, Pier Paolo.

Nat Methods; 18(3): 293-302, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33649590

5.

beta-tting on p63 as a metastatic suppressor.

Clohessy, John G; Pandolfi, Pier Paolo.

Cell; 137(1): 28-30, 2009 Apr 03.

Artículo en Inglés | MEDLINE | ID: mdl-19345184

6.

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Tan, Justin L; Fogley, Rachel D; Flynn, Ryan A; Ablain, Julien; Yang, Song; Saint-André, Violaine; Fan, Zi Peng; Do, Brian T; Laga, Alvaro C; Fujinaga, Koh; Santoriello, Cristina; Greer, Celeste B; Kim, Yoon Jung; Clohessy, John G; Bothmer, Anne; Pandell, Nicole; Avagyan, Serine; Brogie, John E; van Rooijen, Ellen; Hagedorn, Elliott J; Shyh-Chang, Ng; White, Richard M; Price, David H; Pandolfi, Pier Paolo; Peterlin, B Matija; Zhou, Yi; Kim, Tae Hoon; Asara, John M; Chang, Howard Y; Young, Richard A; Zon, Leonard I.

Mol Cell; 62(1): 34-46, 2016 Apr 07.

Artículo en Inglés | MEDLINE | ID: mdl-27058786

7.

Toker Cell Hyperplasia in the Nipple-Areolar Complex of Transmasculine Individuals.

Baker, Gabrielle M; Bret-Mounet, Vanessa C; Xu, Jingxiong; Fein-Zachary, Valerie J; Tobias, Adam M; Bartlett, Richard A; Clohessy, John G; Vlachos, Ioannis S; Massicott, Erica S; Wulf, Gerburg M; Schnitt, Stuart J; Heng, Yujing J.

Mod Pathol; 36(6): 100121, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-36889065

8.

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, Akinobu; Pasut, Alessandra; Matsumoto, Masaki; Yamashita, Riu; Fung, Jacqueline; Monteleone, Emanuele; Saghatelian, Alan; Nakayama, Keiichi I; Clohessy, John G; Pandolfi, Pier Paolo.

Nature; 541(7636): 228-232, 2017 01 12.

Artículo en Inglés | MEDLINE | ID: mdl-28024296

9.

Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment.

Maroni, Giorgia; Krishnan, Indira; Alfieri, Roberta; Maymi, Valerie A; Pandell, Nicole; Csizmadia, Eva; Zhang, Junyan; Weetall, Marla; Branstrom, Art; Braccini, Giulia; Cabrera San Millán, Eva; Storti, Barbara; Bizzarri, Ranieri; Kocher, Olivier; Daniela Sanchez Bassères, Daniela S; Welner, Robert S; Magli, Maria Cristina; Merelli, Ivan; Clohessy, John G; Ali, Azhar; Tenen, Daniel G; Levantini, Elena.

Cancer Res Commun; 4(3): 919-937, 2024 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-38546390

10.

Reciprocal antagonism of PIN1-APC/C^CDH1 governs mitotic protein stability and cell cycle entry.

Ke, Shizhong; Dang, Fabin; Wang, Lin; Chen, Jia-Yun; Naik, Mandar T; Li, Wenxue; Thavamani, Abhishek; Kim, Nami; Naik, Nandita M; Sui, Huaxiu; Tang, Wei; Qiu, Chenxi; Koikawa, Kazuhiro; Batalini, Felipe; Stern Gatof, Emily; Isaza, Daniela Arango; Patel, Jaymin M; Wang, Xiaodong; Clohessy, John G; Heng, Yujing J; Lahav, Galit; Liu, Yansheng; Gray, Nathanael S; Zhou, Xiao Zhen; Wei, Wenyi; Wulf, Gerburg M; Lu, Kun Ping.

Nat Commun; 15(1): 3220, 2024 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-38622115

11.

Targeting of microRNA-22 Suppresses Tumor Spread in a Mouse Model of Triple-Negative Breast Cancer.

Panella, Riccardo; Cotton, Cody A; Maymi, Valerie A; Best, Sachem; Berry, Kelsey E; Lee, Samuel; Batalini, Felipe; Vlachos, Ioannis S; Clohessy, John G; Kauppinen, Sakari; Pandolfi, Pier Paolo.

Biomedicines; 11(5)2023 05 18.

Artículo en Inglés | MEDLINE | ID: mdl-37239141

12.

Reciprocal inhibition of PIN1 and APC/C_CDH1 controls timely G1/S transition and creates therapeutic vulnerability.

Ke, Shizhong; Dang, Fabin; Wang, Lin; Chen, Jia-Yun; Naik, Mandar T; Thavamani, Abhishek; Liu, Yansheng; Li, Wenxue; Kim, Nami; Naik, Nandita M; Sui, Huaxiu; Tang, Wei; Qiu, Chenxi; Koikawa, Kazuhiro; Batalini, Felipe; Wang, Xiaodong; Clohessy, John G; Heng, Yujing Jan; Lahav, Galit; Gray, Nathanael S; Zho, Xiao Zhen; Wei, Wenyi; Wulf, Gerburg M; Lu, Kun Ping.

Res Sq; 2023 Jan 19.

Artículo en Inglés | MEDLINE | ID: mdl-36711754

13.

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.

Cheng, Ke; Sportoletti, Paolo; Ito, Keisuke; Clohessy, John G; Teruya-Feldstein, Julie; Kutok, Jeffery L; Pandolfi, Pier Paolo.

Blood; 115(16): 3341-5, 2010 Apr 22.

Artículo en Inglés | MEDLINE | ID: mdl-19666870

14.

NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.

Morel, Katherine L; Hamid, Anis A; Clohessy, John G; Pandell, Nicole; Ellis, Leigh; Sweeney, Christopher J.

Mol Cancer Res; 19(7): 1137-1145, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33863813

15.

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs.

Zhang, Yang; Nguyen, Tuan M; Zhang, Xiao-Ou; Wang, Limei; Phan, Tin; Clohessy, John G; Pandolfi, Pier Paolo.

Genome Biol; 22(1): 41, 2021 01 21.

Artículo en Inglés | MEDLINE | ID: mdl-33478577

16.

WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.

Kishikawa, Takahiro; Higuchi, Hiroshi; Wang, Limei; Panch, Nivedita; Maymi, Valerie; Best, Sachem; Lee, Samuel; Notoya, Genso; Toker, Alex; Matesic, Lydia E; Wulf, Gerburg M; Wei, Wenyi; Otsuka, Motoyuki; Koike, Kazuhiko; Clohessy, John G; Lee, Yu-Ru; Pandolfi, Pier Paolo.

J Clin Invest; 131(24)2021 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-34907909

17.

Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors.

Chaudagar, Kiranj Kishor; Landon-Brace, Natalie; Solanki, Aniruddh; Hieromnimon, Hanna M; Hegermiller, Emma; Li, Wen; Shao, Yue; Joseph, John; Wilkins, Devan J; Bynoe, Kaela M; Li, Xiang-Ling; Clohessy, John G; Ullas, Soumya; Karp, Jeffrey M; Patnaik, Akash.

Mol Cancer Ther; 20(2): 438-449, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33277441

18.

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.

Maroni, Giorgia; Bassal, Mahmoud A; Krishnan, Indira; Fhu, Chee Wai; Savova, Virginia; Zilionis, Rapolas; Maymi, Valerie A; Pandell, Nicole; Csizmadia, Eva; Zhang, Junyan; Storti, Barbara; Castaño, Julio; Panella, Riccardo; Li, Jia; Gustafson, Corinne E; Fox, Sam; Levy, Rachel D; Meyerovitz, Claire V; Tramontozzi, Peter J; Vermilya, Kimberly; De Rienzo, Assunta; Crucitta, Stefania; Bassères, Daniela S; Weetall, Marla; Branstrom, Art; Giorgetti, Alessandra; Ciampi, Raffaele; Del Re, Marzia; Danesi, Romano; Bizzarri, Ranieri; Yang, Henry; Kocher, Olivier; Klein, Allon M; Welner, Robert S; Bueno, Raphael; Magli, Maria Cristina; Clohessy, John G; Ali, Azhar; Tenen, Daniel G; Levantini, Elena.

Commun Biol; 4(1): 370, 2021 04 14.

Artículo en Inglés | MEDLINE | ID: mdl-33854168

19.

Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Lunardi, Andrea; Ala, Ugo; Epping, Mirjam T; Salmena, Leonardo; Clohessy, John G; Webster, Kaitlyn A; Wang, Guocan; Mazzucchelli, Roberta; Bianconi, Maristella; Stack, Edward C; Lis, Rosina; Patnaik, Akash; Cantley, Lewis C; Bubley, Glenn; Cordon-Cardo, Carlos; Gerald, William L; Montironi, Rodolfo; Signoretti, Sabina; Loda, Massimo; Nardella, Caterina; Pandolfi, Pier Paolo.

Nat Genet; 52(10): 1132, 2020 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-32884149

20.

The Tug1 lncRNA locus is essential for male fertility.

Lewandowski, Jordan P; Dumbovic, Gabrijela; Watson, Audrey R; Hwang, Taeyoung; Jacobs-Palmer, Emily; Chang, Nydia; Much, Christian; Turner, Kyle M; Kirby, Christopher; Rubinstein, Nimrod D; Groff, Abigail F; Liapis, Steve C; Gerhardinger, Chiara; Bester, Assaf; Pandolfi, Pier Paolo; Clohessy, John G; Hoekstra, Hopi E; Sauvageau, Martin; Rinn, John L.

Genome Biol; 21(1): 237, 2020 09 07.

Artículo en Inglés | MEDLINE | ID: mdl-32894169

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